Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation

Damaged mitochondria are eliminated through autophagy machinery. A cytosolic E3 ubiquitin ligase Parkin, a gene product mutated in familial Parkinsonism, is essential for this pathway. Recent progress has revealed that phosphorylation of both Parkin and ubiquitin at Ser(65) by PINK1 are crucial for...

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Vydáno v:J Biol Chem
Hlavní autoři: Yamano, Koji, Queliconi, Bruno B., Koyano, Fumika, Saeki, Yasushi, Hirokawa, Takatsugu, Tanaka, Keiji, Matsuda, Noriyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646171/
https://ncbi.nlm.nih.gov/pubmed/26260794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.671446
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