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Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation
Damaged mitochondria are eliminated through autophagy machinery. A cytosolic E3 ubiquitin ligase Parkin, a gene product mutated in familial Parkinsonism, is essential for this pathway. Recent progress has revealed that phosphorylation of both Parkin and ubiquitin at Ser(65) by PINK1 are crucial for...
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| Publicado en: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646171/ https://ncbi.nlm.nih.gov/pubmed/26260794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.671446 |
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