Endosomal Rab cycles regulate Parkin-mediated mitophagy

Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autoph...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Yamano, Koji, Wang, Chunxin, Sarraf, Shireen A, Münch, Christian, Kikuchi, Reika, Noda, Nobuo N, Hizukuri, Yohei, Kanemaki, Masato T, Harper, Wade, Tanaka, Keiji, Matsuda, Noriyuki, Youle, Richard J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2018
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780041/
https://ncbi.nlm.nih.gov/pubmed/29360040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31326
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