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Structural Insights into Amyloid Oligomers of the Parkinson Disease-related Protein α-Synuclein
The presence of intraneuronal deposits mainly formed by amyloid fibrils of the presynaptic protein α-synuclein (AS) is a hallmark of Parkinson disease. Currently, neurotoxicity is attributed to prefibrillar oligomeric species rather than the insoluble aggregates, although their mechanisms of toxicit...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175316/ https://ncbi.nlm.nih.gov/pubmed/25143382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566695 |
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