Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes. By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors o...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Richter, Benjamin, Sliter, Danielle A., Herhaus, Lina, Stolz, Alexandra, Wang, Chunxin, Beli, Petra, Zaffagnini, Gabriele, Wild, Philipp, Martens, Sascha, Wagner, Sebastian A., Youle, Richard J., Dikic, Ivan
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2016
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839414/
https://ncbi.nlm.nih.gov/pubmed/27035970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523926113
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