CDK8/9 drive Smad transcriptional action, turnover and YAP interactions in BMP and TGFβ pathways

TGFβ and BMP receptor kinases activate Smad transcription factors by C-terminal phosphorylation. We have identified a subsequent agonist-induced phosphorylation that plays a central dual role in Smad transcriptional activation and turnover. As receptor-activated Smads form transcriptional complexes,...

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Main Authors: Alarcón, Claudio, Zaromytidou, Alexia-Ileana, Xi, Qiaoran, Gao, Sheng, Yu, Jianzhong, Fujisawa, Sho, Barlas, Afsar, Miller, Alexandria N., Manova-Todorova, Katia, Macias, Maria J., Sapkota, Gopal, Pan, Duojia, Massagué, Joan
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818353/
https://ncbi.nlm.nih.gov/pubmed/19914168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.09.035
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