A Smad action turnover switch operated by WW domain readers of a phosphoserine code

When directed to the nucleus by TGF-β or BMP signals, Smad proteins undergo cyclin-dependent kinase 8/9 (CDK8/9) and glycogen synthase kinase-3 (GSK3) phosphorylations that mediate the binding of YAP and Pin1 for transcriptional action, and of ubiquitin ligases Smurf1 and Nedd4L for Smad destruction...

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Detalhes bibliográficos
Main Authors: Aragón, Eric, Goerner, Nina, Zaromytidou, Alexia-Ileana, Xi, Qiaoran, Escobedo, Albert, Massagué, Joan, Macias, Maria J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127429/
https://ncbi.nlm.nih.gov/pubmed/21685363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2060811
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