Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

Smad transcription factors are key signal transducers for the TGF-β/bone morphogenetic protein (BMP) family of cytokines and morphogens. C-terminal serine phosphorylation by TGF-β and BMP membrane receptors drives Smads into the nucleus as transcriptional regulators. Dephosphorylation and recycling...

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Bibliografske podrobnosti
Main Authors: Knockaert, Marie, Sapkota, Gopal, Alarcón, Claudio, Massagué, Joan, Brivanlou, Ali H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567677/
https://ncbi.nlm.nih.gov/pubmed/16882717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605133103
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