Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. Here we report the existence of a natural inhibitor of this process, Smad6, a longer version of the previously reported JV15-...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Genes Dev
Hauptverfasser:	Hata, Akiko, Lagna, Giorgio, Massagué, Joan, Hemmati-Brivanlou, Ali
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 1998
Schlagworte:	Research Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316444/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9436979/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.2.186
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!