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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. Here we report the existence of a natural inhibitor of this process, Smad6, a longer version of the previously reported JV15-...

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Main Authors: Hata, Akiko, Lagna, Giorgio, Massagué, Joan, Hemmati-Brivanlou, Ali
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 1998
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC316444/
https://ncbi.nlm.nih.gov/pubmed/9436979
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