Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. Here we report the existence of a natural inhibitor of this process, Smad6, a longer version of the previously reported JV15-...
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| Udgivet i: | Genes Dev |
|---|---|
| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
1998
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316444/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9436979/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.2.186 |
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