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Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
Upon ligand binding, the receptors of the TGFβ family phosphorylate Smad proteins, which then move into the nucleus where they activate transcription. To carry out this function, the receptor-activated Smads 1 and 2 require association with the product of deleted in pancreatic carcinoma, locus 4 (DP...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
1997
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC316747/ https://ncbi.nlm.nih.gov/pubmed/9389648 |
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