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Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β
Transforming growth factor-β (TGF-β) arrests growth of epithelial cells by inducing the transcription of p15(Ink4B), a cyclin-dependent kinase inhibitor. In this study, we demonstrate that p15(Ink4B) induction was mediated by a TGF-β-induced complex of Smad2, Smad3, Smad4 and Sp1. Mutations in the S...
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| Published in: | EMBO J |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2000
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302105/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11013220/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.19.5178 |
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