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A mechanism of repression of TGFβ/ Smad signaling by oncogenic Ras

TGFβ can override the proliferative effects of EGF and other Ras-activating mitogens in normal epithelial cells. However, epithelial cells harboring oncogenic Ras mutations often show a loss of TGFβ antimitogenic responses. Here we report that oncogenic Ras inhibits TGFβ signaling in mammary and lun...

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Bibliografische gegevens
Hoofdauteurs: Kretzschmar, Marcus, Doody, Jacqueline, Timokhina, Inna, Massagué, Joan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316599/
https://ncbi.nlm.nih.gov/pubmed/10197981
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