A mechanism of repression of TGFβ/ Smad signaling by oncogenic Ras

TGFβ can override the proliferative effects of EGF and other Ras-activating mitogens in normal epithelial cells. However, epithelial cells harboring oncogenic Ras mutations often show a loss of TGFβ antimitogenic responses. Here we report that oncogenic Ras inhibits TGFβ signaling in mammary and lun...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Kretzschmar, Marcus, Doody, Jacqueline, Timokhina, Inna, Massagué, Joan
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1999
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316599/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10197981/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.7.804
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