A mechanism of repression of TGFβ/ Smad signaling by oncogenic Ras
TGFβ can override the proliferative effects of EGF and other Ras-activating mitogens in normal epithelial cells. However, epithelial cells harboring oncogenic Ras mutations often show a loss of TGFβ antimitogenic responses. Here we report that oncogenic Ras inhibits TGFβ signaling in mammary and lun...
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| Pubblicato in: | Genes Dev |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316599/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10197981/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.7.804 |
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