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IDH1 and IDH2: Not Your Typical Oncogenes
Oncogenes usually increase their normal function when activated. But seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.
Kaydedildi:
| Yayımlandı: | Cancer Cell |
|---|---|
| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4467912/ https://ncbi.nlm.nih.gov/pubmed/20227034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.02.024 |
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