Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

Por Reitman, Zachary J., Yan, Hai
Publicado em 2010

Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors

Por Reitman, Zachary J., Pirozzi, Christopher J., Yan, Hai
Publicado em 2013

Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors

Por Pirozzi, Christopher J., Reitman, Zachary J., Yan, Hai
Publicado no Cancer Cell (2013)

IDH1 and IDH2: Not Your Typical Oncogenes

Por Reitman, Zachary J., Parsons, D. Williams, Yan, Hai
Publicado no Cancer Cell (2010)

Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila

Por Reitman, Zachary J., Sinenko, Sergey A., Spana, Eric P., Yan, Hai
Publicado no Blood (2015)

Relationship Between Time of First Publication and Subsequent Publication Success Among Non-PhD Physician-Scientists

Por Riggs, Kevin R., Reitman, Zachary J., Mielenz, Thelma J., Goodman, Philip C.
Publicado em 2012

Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs

Por Chitneni, Satish K., Reitman, Zachary J., Gooden, David M., Yan, Hai, Zalutsky, Michael R.
Publicado no Eur J Med Chem (2016)

Enzyme Redesign Guided by Cancer-Derived IDH1 Mutations

Por Reitman, Zachary J., Choi, Bryan D., Spasojevic, Ivan, Bigner, Darell D., Sampson, John H., Yan, Hai
Publicado em 2012

Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors

Por Chitneni, Satish K., Reitman, Zachary J., Spicehandler, Rebecca, Gooden, David M., Yan, Hai, Zalutsky, Michael R.
Publicado no Bioorg Med Chem Lett (2018)

Picornavirus genome replication: Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structura...

Por Shen, Miaoqing, Reitman, Zachary J., Zhao, Yan, Moustafa, Ibrahim, Wang, Qixin, Arnold, Jamie J., Pathak, Harsh B., Cameron, Craig E.
Publicado em 2007

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP(+)-Dependent Isocitrate Dehydrogenase Mutations

Por Jin, Genglin, Reitman, Zachary J., Spasojevic, Ivan, Batinic-Haberle, Ines, Yang, Jian, Schmidt-Kittler, Oleg, Bigner, Darell D., Yan, Hai
Publicado em 2011

IDH1 mutation identified in human melanoma

Por Lopez, Giselle Y., Reitman, Zachary J., Solomon, David, Waldman, Todd, Bigner, Darell D., McLendon, Roger E., Samuels, Yardena, Yan, Hai
Publicado em 2010

IDH1 and IDH2 hotspot mutations are not found in canine glioma

Por Reitman, Zachary J., Olby, Natasha J., Mariani, Christopher L., Thomas, Rachael, Breen, Matthew, Bigner, Darrell D., McLendon, Roger E., Yan, Hai
Publicado em 2010

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

Por Reitman, Zachary J., Jin, Genglin, Karoly, Edward D., Spasojevic, Ivan, Yang, Jian, Kinzler, Kenneth W., He, Yiping, Bigner, Darell D., Vogelstein, Bert, Yan, Hai
Publicado em 2011

Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia

Por Reitman, Zachary J., Duncan, Christopher G., Poteet, Ethan, Winters, Ali, Yan, Liang-Jun, Gooden, David M., Spasojevic, Ivan, Boros, Laszlo G., Yang, Shao-Hua, Yan, Hai
Publicado em 2014

Disruption of wild type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas

Por Jin, Genglin, Reitman, Zachary J., Duncan, Chritopher G., Spasojevic, Ivan, Gooden, David M., Rasheed, B. Ahmed, Yang, Rui, Lopez, Giselle Y., He, Yiping, McLendon, Roger E., Bigner, Darell D., Yan, Hai
Publicado em 2012

The genetic landscape of anaplastic astrocytoma

Por Killela, Patrick J., Pirozzi, Christopher J., Reitman, Zachary J., Jones, Sian, Rasheed, B. Ahmed, Lipp, Eric, Friedman, Henry, Friedman, Allan H., He, Yiping, McLendon, Roger E., Bigner, Darell D., Yan, Hai
Publicado em 2013

DIPG-12. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)

Por Khadka, Prasidda, Reitman, Zachary J, Buchan, Graham, Hartley, Rachel, Bear, Heather, Georgis, Yohanna, Jarmale, Spandana, Schoolcraft, Kathleen, Miller, Peter, Stiles, Charles D, Chowdhury, Dipanjan, Haas-Kogan, Daphne, Johannessen, Cory, Ebert, Benjamin L, Ligon, Keith L, Phoenix, Timothy, Beroukhim, Rameen, Bandopadhayay, Pratiti
Publicado no Neuro Oncol (2019)

The genome-wide mutational landscape of pituitary adenomas

Por Song, Zhi-Jian, Reitman, Zachary J, Ma, Zeng-Yi, Chen, Jian-Hua, Zhang, Qi-Lin, Shou, Xue-Fei, Huang, Chuan-Xin, Wang, Yong-Fei, Li, Shi-Qi, Mao, Ying, Zhou, Liang-Fu, Lian, Bao-Feng, Yan, Hai, Shi, Yong-Yong, Zhao, Yao
Publicado no Cell Res (2016)

Exomic Sequencing of Four Rare Central Nervous System Tumor Types

Por Bettegowda, Chetan, Agrawal, Nishant, Jiao, Yuchen, Wang, Yuxuan, Wood, Laura D., Rodriguez, Fausto J., Hruban, Ralph H., Gallia, Gary L., Binder, Zev A., Riggins, Callen J., Salmasi, Vafi, Riggins, Gregory J., Reitman, Zachary J., Rasheed, Ahmed, Keir, Stephen, Shinjo, Sueli, Marie, Suely, McLendon, Roger, Jallo, George, Vogelstein, Bert, Bigner, Darell, Yan, Hai, Kinzler, Kenneth W., Papadopoulos, Nickolas
Publicado em 2013