ET-28 COMBINATION THERAPY WITH MET TYROSINE KINASE INHIBITOR EMD1214063 AND BEVACIZUMAB

по Keir, Stephen, Roskoski, Martin, Gasinski, Danuta, Friedman, Henry, Bigner, Darell
Опубликовано 2014

LGG-01. EVALUATION OF COBIMETINIB, A MEK INHIBITOR, IN LOW-GRADE PEDIATRIC BRAIN TUMORS

по Roskoski, Martin, Gasinski, Danuta, Friedman, Henry, Bigner, Darell, Keir, Stephen
Опубликовано в: Neuro Oncol (2018)

EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity

по Zhu, Hu, Cao, Xinyu, Ali-Osman, Francis, Keir, Stephen, Lo, Hui-Wen
Опубликовано 2010

[(177)Lu]-DOTA(0)-Tyr(3)-octreotate: A Potential Targeted Radiotherapeutic for the Treatment of Medulloblastoma

по Vaidyanathan, Ganesan, Affleck, Donna J., Zhao, Xiao-Guang, Keir, Stephen T., Zalutsky, Michael R.
Опубликовано 2010

Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells’ VEGF production an...

по Bota, Daniela A., Alexandru, Daniela, Keir, Stephen T., Bigner, Darell, Vredenburgh, James, Friedman, Henry S.
Опубликовано в: J Neurosurg (2013)

Cellular Redox Modulator, ortho Mn(III) meso-tetrakis(N-n-Hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the Treatment of Brain Tumors

по Keir, Stephen T., Dewhirst, Mark W., Kirkpatrick, John P., Bigner, Darell D., Batinic-Haberle, Ines
Опубликовано 2011

Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies

по Choudhury, Kingshuk Roy, Keir, Stephen T., Ashcraft, Kathleen A., Boss, Mary-Keara, Dewhirst, Mark W.
Опубликовано в: Oncotarget (2015)

Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppres...

по Okamura, Tatsunori, Antoun, Gamil, Keir, Stephen T., Friedman, Henry, Bigner, Darell D., Ali-Osman, Francis
Опубликовано в: J Biol Chem (2015)

TMOD-33. ESTABLISHMENT AND PRELIMINARY EVALUATION OF BEVACIZUMAB-RESISTANT GLIOMA XENOGRAFT MODELS

по Keir, Stephen, Waitkus, Matthew, Roskoski, Martin, Friedman, Henry, Bigner, Darell, Yan, Hai, Ashley, David
Опубликовано в: Neuro Oncol (2018)

Initial Testing of VNP40101M (Cloretazine(®)) by the Pediatric Preclinical Testing Program

по Keir, Stephen T., Morton, Christopher L., Billups, Catherine, Smith, Malcolm A., Houghton, Peter J., Gururangan, Sridharan
Опубликовано 2008

IDENTIFICATION AND PRELIMINARY TREATMENT DATA OF XENOGRAFTS REPRESENTING TCGA-DEFINED SUBTYPES

по Keir, Stephen T., Roskoski, Martin A., Gasinski, Danuta, Kwatra, Madan K., Friedman, Henry S., Bigner, Darell D.
Опубликовано 2014

Initial Testing of the Multitargeted Kinase Inhibitor Pazopanib by the Pediatric Preclinical Testing Program

по Keir, Stephen T., Morton, Christopher L., Wu, Jianrong, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A.
Опубликовано в: Pediatr Blood Cancer (2011)

PATIENT-DERIVED XENOGRAFTS MIRROR THE PROTEOMIC PROFILE OF HUMAN GLIOBLASTOMA: IMPLICATIONS FOR PERSONALIZED DRUG DEVELOPMENT

по Kwatra, Madan M., Brown, Kristine E., Chagoya, Gustavo, Keir, Stephen T., Bigner, Darell D., Sampson, John H.
Опубликовано 2014

Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas

по Kuan, Chien-Tsun, Wakiya, Kenji, Keir, Stephen T., Li, Jianjun, Herndon, James E., Pastan, Ira, Bigner, Darell D.
Опубликовано 2010

TMOD-27. EFFICACY OF SOLUBLE PANOBINOSTAT (MTX110) IN PRECLINICAL MODELS OF ADULT GLIOBLASTOMA

по Ashley, David, Keir, Stephen T, Roskoski, Martin A, Davies, Rhian, Williams, Ben, Damment, Stephen J P, Conlon, Kelly
Опубликовано в: Neuro Oncol (2020)

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors

по Yu, Xin, Dobrikov, Mikhail, Keir, Stephen T., Gromeier, Matthias, Pastan, Ira H., Reisfeld, Ralph, Bigner, Darell D., Chandramohan, Vidyalakshmi
Опубликовано в: PLoS One (2019)

Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice

по Badruddoja, Michael A., Keir, Stephen T., King, Ivan, Zeidner, Joseph, Vredenburgh, James J., Muhlbaier, Lawrence H., Bigner, Darell D., Friedman, Henry S.
Опубликовано 2007

Antitumor efficacy of D2C7-(scdsFv)-PE38KDEL, a novel immunotoxin targeting EGFRwt and EGFRvIII, by convection-enhanced delivery in orthotopic brain tumor mouse models

по Bao, Xuhui, Chandramohan, Vidyalakshmi, Keir, Stephen T, Pegram, Charles N, McLendon, Roger E, Kuan, Chien-Tsun, Pastan, Ira H, Bigner, Darell D
Опубликовано 2013

Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors

по Chandramohan, Vidyalakshmi, Bao, Xuhui, Kaneko, Mika Kato, Kato, Yukinari, Keir, Stephen T., Szafranski, Scott E., Kuan, Chien-Tsun, Pastan, Ira H., Bigner, Darell D.
Опубликовано 2012

Affinity-matured recombinant immunotoxin targeting gangliosides 3′-isoLM1 and 3′,6'-isoLD1 on malignant gliomas

по Piao, Hailan, Kuan, Chien-Tsun, Chandramohan, Vidya, Keir, Stephen T, Pegram, Charles N, Bao, Xuhui, Månsson, Jan-Eric, Pastan, Ira H, Bigner, Darell D
Опубликовано 2013