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Initial Testing of VNP40101M (Cloretazine(®)) by the Pediatric Preclinical Testing Program

VNP40101M is a novel alkylating agent that yields two reactive compounds (a chloroethylating species and methylisocyanate) and has demonstrated activity against a wide spectrum of tumor xenografts. VNP40101M was tested against an in vivo panel of 5 pediatric brain tumor xenografts at a dose of 18 mg...

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Detalhes bibliográficos
Main Authors: Keir, Stephen T., Morton, Christopher L., Billups, Catherine, Smith, Malcolm A., Houghton, Peter J., Gururangan, Sridharan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836208/
https://ncbi.nlm.nih.gov/pubmed/18493996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.21620
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