Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice

VNP40101M, or 1,2-bis(methylsulfonyl)-1-(2-choloro-ethyl)-2-(methylamino)carbonylhydrazine (Cloretazine), is a bifunctional prodrug that belongs to a class of DNA-modifying agents—the sulfonylhydrazines—that has been synthesized and been shown to have activity against a wide spectrum of xenografts....

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Autori principali: Badruddoja, Michael A., Keir, Stephen T., King, Ivan, Zeidner, Joseph, Vredenburgh, James J., Muhlbaier, Lawrence H., Bigner, Darell D., Friedman, Henry S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Duke University Press 2007
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1907418/
https://ncbi.nlm.nih.gov/pubmed/17522334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2007-011
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