Initial Testing of Aplidin by the Pediatric Preclinical Testing Program

Aplidin was tested in vitro at concentrations ranging from from 0.1 nM to 1.0 μM and in vivo at a dose of 0.6 mg/kg administered intraperitoneally on an every 4 days × 3 schedule that was repeated at day 21. In vitro, Aplidin was most active against acute lymphoblastic leukemia (ALL) cell lines. In...

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Autores principales: Morton, Christopher L., Houghton, Peter J., Gorlick, Richard, Kolb, E. Anders, Lock, Richard, Carol, Hernan, Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Maris, John M., Billups, Catherine, Smith, Malcolm A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777698/
https://ncbi.nlm.nih.gov/pubmed/19418543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.21976
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