Initial Testing (Stage 1) of the Kinesin Spindle Protein Inhibitor Ispinesib by the Pediatric Preclinical Testing Program

BACKGROUND: Ispinesib is a highly specific inhibitor of kinesin spindle protein (KSP, HsEg5), a mitotic kinesin required for separation of the spindle poles. Here we report the activity of ispinesib against the in vitro and in vivo panels of the Pediatric Preclinical Testing Program (PPTP). PROCEDUR...

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Main Authors: Carol, Hernan, Lock, Richard, Houghton, Peter J., Morton, Christopher L., Kolb, E. Anders, Gorlick, Richard, Reynolds, C. Patrick, Maris, John M., Keir, Stephen T., Billups, Catherine A., Smith, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763980/
https://ncbi.nlm.nih.gov/pubmed/19554570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22056
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