Initial Testing (Stage 1) of the Kinesin Spindle Protein Inhibitor Ispinesib by the Pediatric Preclinical Testing Program

BACKGROUND: Ispinesib is a highly specific inhibitor of kinesin spindle protein (KSP, HsEg5), a mitotic kinesin required for separation of the spindle poles. Here we report the activity of ispinesib against the in vitro and in vivo panels of the Pediatric Preclinical Testing Program (PPTP). PROCEDUR...

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Hauptverfasser: Carol, Hernan, Lock, Richard, Houghton, Peter J., Morton, Christopher L., Kolb, E. Anders, Gorlick, Richard, Reynolds, C. Patrick, Maris, John M., Keir, Stephen T., Billups, Catherine A., Smith, Malcolm A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763980/
https://ncbi.nlm.nih.gov/pubmed/19554570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22056
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