Initial Testing (Stage 1) of the IGF-1 Receptor Inhibitor BMS-754807 by the Pediatric Preclinical Testing Program

BACKGROUND: BMS-754807 is a small molecule ATP-competitive inhibitor of the type-1 insulin-like growth factor receptor currently in phase 1 clinical trials. PROCEDURES: BMS-754807 was tested against the Pediatric Preclinical Testing Program (PPTP) in vitro panel at concentrations ranging from 1.0 nM...

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Publicado no:Pediatr Blood Cancer
Main Authors: Kolb, E. Anders, Gorlick, Richard, Lock, Richard, Carol, Hernan, Morton, Christopher L., Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Maris, John M., Billups, Catherine, Smith, Malcolm A., Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263954/
https://ncbi.nlm.nih.gov/pubmed/21298745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22741
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