Initial Testing (Stage 1) of LCL161, a SMAC Mimetic, by the Pediatric Preclinical Testing Program

LCL161, a SMAC mimetic, was tested against the PPTP in vitro panel (1.0 nM to 10.0 μM) and the PPTP in vivo panels (30 mg/kg or 75 mg/kg [solid tumors] or 100 mg/kg [ALL]) administered orally twice weekly. LCL161 showed a median relative IC(50) value of >10 μM, being more potent against several l...

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Autori principali: Houghton, Peter J., Kang, Min H., Reynolds, C. Patrick, Morton, Christopher L., Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Carol, Hernan, Lock, Richard, Maris, John M., Billups, Catherine A., Smith, Malcolm A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253328/
https://ncbi.nlm.nih.gov/pubmed/21681929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23167
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