Initial Testing (Stage 1) of the Akt Inhibitor GSK690693 by the Pediatric Preclinical Testing Program

BACKGROUND: GSK690693 is a small molecule ATP-competitive inhibitor of the pro-survival kinase Akt. Since Akt regulates multiple downstream targets including transcription factors, glycogen synthase 3, the pro-apoptotic protein Bad, as well as MDM2 and mTORC1, it was tested against the in vitro and...

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Main Authors: Carol, Hernan, Morton, Christopher L., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Maris, John M., Billups, Catherine, Smith, Malcolm A., Houghton, Peter J., Lock, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965797/
https://ncbi.nlm.nih.gov/pubmed/20740623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22710
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