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Initial Testing of the CENP-E Inhibitor GSK923295Aby the Pediatric Preclinical Testing Program
BACKGROUND: The centromere kinesin motor protein CENP-E plays a crucial role in mitosis, and is an appealing molecular target in cancer. GSK923295A is an allosteric inhibitor of CENP-E that is undergoing clinical evaluation. PROCEDURES: GSK923295A was evaluated against the 23 cell lines in the Pedia...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3163687/ https://ncbi.nlm.nih.gov/pubmed/21584937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23176 |
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