Initial Testing of the CENP-E Inhibitor GSK923295Aby the Pediatric Preclinical Testing Program

BACKGROUND: The centromere kinesin motor protein CENP-E plays a crucial role in mitosis, and is an appealing molecular target in cancer. GSK923295A is an allosteric inhibitor of CENP-E that is undergoing clinical evaluation. PROCEDURES: GSK923295A was evaluated against the 23 cell lines in the Pedia...

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Main Authors: Lock, Richard B., Carol, Hernan, Morton, Christopher L., Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Maris, John M., Wozniak, Amy W., Gorlick, Richard, Kolb, E. Anders, Houghton, Peter J., Smith, Malcolm A.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163687/
https://ncbi.nlm.nih.gov/pubmed/21584937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23176
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