Initial Testing (Stage 1) of the Polyamine Analog PG11047 by the Pediatric Preclinical Testing Program

BACKGROUND: PG11047 is a novel conformationally restricted analog of the natural polyamine spermine that lowers cellular endogenous polyamine levels and competitively inhibits natural polyamine functions leading to cancer cell growth inhibition. The activity of PG11047 was evaluated against the PPTP...

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Main Authors: Smith, Malcolm A., Maris, John M., Lock, Richard, Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Carol, Hernan, Morton, Christopher L., Reynolds, C. Patrick, Kang, Min H., Houghton, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115432/
https://ncbi.nlm.nih.gov/pubmed/21360650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22797
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