Initial Testing (Stage 1) of Vorinostat (SAHA) by the Pediatric Preclinical Testing Program

Vorinostat, a histone deacetylase inhibitor, was evaluated against the in vitro and in vivo childhood solid tumor and leukemia models in the Pediatric Preclinical Testing Program (PPTP). In vitro testing was performed by the DIMSCAN cytotoxicity assay. In vivo, vorinostat was administered intraperit...

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Hauptverfasser: Keshelava, Nino, Houghton, Peter J., Morton, Christopher L., Lock, Richard B., Carol, Hernan, Keir, Stephen T., Maris, John M., Reynolds, C Patrick, Gorlick, Richard, Kolb, E. Anders, Wu, Jianrong, Smith, Malcolm A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752378/
https://ncbi.nlm.nih.gov/pubmed/19418547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.21988
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