Initial Testing (Stage 1) of Lapatinib by the Pediatric Preclinical Testing Program

BACKGROUND: Lapatinib is a small molecule reversible tyrosine kinase inhibitor of EGFR and ErbB2 that shows in vitro and in vivo activity against a range of EGFR and ErbB2-dependent adult cancer cell lines and that has clinical efficacy against ErbB2-overexpressing breast cancer. METHODS: Lapatinib...

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Autori principali: Gorlick, Richard, Kolb, E. Anders, Houghton, Peter J., Morton, Christopher L., Phelps, Doris, Schaiquevich, Paula, Stewart, Clinton, Keir, Stephen T., Lock, Richard, Carol, Hernan, Reynolds, C. Patrick, Maris, John M., Wu, Jianrong, Smith, Malcolm A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731000/
https://ncbi.nlm.nih.gov/pubmed/19554571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.21989
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