Initial Testing (Stage 1) of the mTOR Kinase Inhibitor AZD8055 by the Pediatric Preclinical Testing Program

BACKGROUND: AZD8055 is a small molecule ATP-competitive inhibitor of the serine/threonine kinase mTOR that regulates cap-dependent translation through the mTORC1 complex and Akt activation through the mTORC2 complex. PROCEDURES: AZD8055 was tested against the PPTP in vitro panel at concentrations ra...

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Bibliografiska uppgifter
I publikationen:Pediatr Blood Cancer
Huvudupphovsmän: Houghton, Peter J., Gorlick, Richard, Kolb, E. Anders, Lock, Richard, Carol, Hernan, Morton, Christopher L., Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Phelps, Doris, Maris, John M., Billups, Catherine, Smith, Malcolm A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304209/
https://ncbi.nlm.nih.gov/pubmed/21337679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22935
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