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Initial Testing (Stage 1) of the mTOR Kinase Inhibitor AZD8055 by the Pediatric Preclinical Testing Program
BACKGROUND: AZD8055 is a small molecule ATP-competitive inhibitor of the serine/threonine kinase mTOR that regulates cap-dependent translation through the mTORC1 complex and Akt activation through the mTORC2 complex. PROCEDURES: AZD8055 was tested against the PPTP in vitro panel at concentrations ra...
Kaydedildi:
| Yayımlandı: | Pediatr Blood Cancer |
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| Asıl Yazarlar: | , , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4304209/ https://ncbi.nlm.nih.gov/pubmed/21337679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22935 |
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