Initial Testing (Stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program

BACKGROUND: AZD6244 (ARRY-142886) is a potent small molecule inhibitor of MEK1/2 that is in phase 2 clinical development. PROCEDURES: AZD6244 was tested against the PPTP in vitro panel (1 nM-10μM). In vivo AZD6244 was tested at a dose of 100 mg/kg administered orally twice daily five days per week f...

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Detalhes bibliográficos
Main Authors: Kolb, E. Anders, Gorlick, Richard, Houghton, Peter J., Morton, Christopher L., Neale, Geoffrey, Keir, Stephen T., Carol, Hernan, Lock, Richard, Phelps, Doris, Kang, Min H., Reynolds, C. Patrick, Maris, John M., Billups, Catherine, Smith, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004092/
https://ncbi.nlm.nih.gov/pubmed/20806365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22576
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