High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)

MEK/ERK activities are increased in many primary lung cancers, and MEK inhibitors have been tested clinically for treatment of non-small cell lung cancers. The molecular mechanisms of resistance to MEK inhibitors have not been clearly demonstrated, however, and no molecular biomarker that can predic...

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Huvudupphovsmän: Meng, Jieru, Peng, Henry, Dai, Bingbing, Guo, Wei, Wang, Li, Ji, Lin, Minna, John D., Chresta, Christine M., Smith, Paul D., Fang, Bingliang, Roth, Jack A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835993/
https://ncbi.nlm.nih.gov/pubmed/19783898
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