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Dermatologic side effects associated with the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886)

BACKGROUND: Selumetinib (AZD6244, ARRY-142886) is a second generation MEK inhibitor that is currently in clinical trials for various solid malignancies. MEK kinase inhibitors are associated with dermatologic toxicities. While reactions affecting the skin, hair and nails to other targeted agents, suc...

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Detalles Bibliográficos
Publicado en:Invest New Drugs
Autores principales: Balagula, Yevgeniy, Barth, Katherine, Busam, Klaus J., Lacouture, Mario E., Chapman, Paul B., Myskowski, Patricia L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691597/
https://ncbi.nlm.nih.gov/pubmed/20978926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9567-3
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