Dermatologic side effects associated with the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886)

BACKGROUND: Selumetinib (AZD6244, ARRY-142886) is a second generation MEK inhibitor that is currently in clinical trials for various solid malignancies. MEK kinase inhibitors are associated with dermatologic toxicities. While reactions affecting the skin, hair and nails to other targeted agents, suc...

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Gepubliceerd in:Invest New Drugs
Hoofdauteurs: Balagula, Yevgeniy, Barth, Katherine, Busam, Klaus J., Lacouture, Mario E., Chapman, Paul B., Myskowski, Patricia L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691597/
https://ncbi.nlm.nih.gov/pubmed/20978926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9567-3
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