MEK inhibitor selumetinib (AZD6244; ARRY-142886) prevents lung metastasis in a triple-negative breast cancer xenograft model

Patients with triple-negative breast cancer (TNBC) have a poor prognosis because TNBC often metastasizes, leading to death. Among patients with TNBC, those with ERK2 (extracellular signal-regulated kinase 2)-overexpressing tumors were at higher risk of death than those with low-ERK2-expressing tumor...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Bartholomeusz, Chandra, Xie, Xuemei, Pitner, Mary Kathryn, Kondo, Kimie, Dadbin, Ali, Lee, Jangsoon, Saso, Hitomi, Smith, Paul D., Dalby, Kevin N., Ueno, Naoto T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674314/
https://ncbi.nlm.nih.gov/pubmed/26384399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0243
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