Initial Testing (Stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program

BACKGROUND: AZD6244 (ARRY-142886) is a potent small molecule inhibitor of MEK1/2 that is in phase 2 clinical development. PROCEDURES: AZD6244 was tested against the PPTP in vitro panel (1 nM-10μM). In vivo AZD6244 was tested at a dose of 100 mg/kg administered orally twice daily five days per week f...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Kolb, E. Anders, Gorlick, Richard, Houghton, Peter J., Morton, Christopher L., Neale, Geoffrey, Keir, Stephen T., Carol, Hernan, Lock, Richard, Phelps, Doris, Kang, Min H., Reynolds, C. Patrick, Maris, John M., Billups, Catherine, Smith, Malcolm A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004092/
https://ncbi.nlm.nih.gov/pubmed/20806365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22576
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi