Initial Testing (Stage 1) of the Investigational mTOR Kinase Inhibitor MLN0128 by the Pediatric Preclinical Testing Program

MLN0128 is an investigational small molecule ATP-competitive inhibitor of the serine/threonine kinase mTOR. MLN0128 was tested against the in vitro panel at concentrations ranging from 0.1 nM to 1 μM and against the PPTP in vivo panels at a dose of 1 mg/kg administered orally daily x 28. In vitro th...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Kang, Min H., Reynolds, C. Patrick, Maris, John M., Gorlick, Richard, Kolb, E. Anders, Lock, Richard, Carol, Hernan, Keir, Stephen T., Wu, Jianrong, Lyalin, Dmitry, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248662/
https://ncbi.nlm.nih.gov/pubmed/24623675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24989
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