Initial Testing (Stage 1) of the Investigational mTOR Kinase Inhibitor MLN0128 by the Pediatric Preclinical Testing Program

MLN0128 is an investigational small molecule ATP-competitive inhibitor of the serine/threonine kinase mTOR. MLN0128 was tested against the in vitro panel at concentrations ranging from 0.1 nM to 1 μM and against the PPTP in vivo panels at a dose of 1 mg/kg administered orally daily x 28. In vitro th...

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Veröffentlicht in:Pediatr Blood Cancer
Hauptverfasser: Kang, Min H., Reynolds, C. Patrick, Maris, John M., Gorlick, Richard, Kolb, E. Anders, Lock, Richard, Carol, Hernan, Keir, Stephen T., Wu, Jianrong, Lyalin, Dmitry, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248662/
https://ncbi.nlm.nih.gov/pubmed/24623675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24989
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