Initial Testing of the Aurora Kinase A Inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)

BACKGROUND: MLN8237 is a small molecule inhibitor of Aurora Kinase A (AURKA) that is currently in early phase clinical testing. AURKA plays a pivotal role in centrosome maturation and spindle formation during mitosis. PROCEDURES: MLN8237 was tested against the Pediatric Preclinical Testing Program (...

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Main Authors: Maris, John M., Morton, Christopher L., Gorlick, Richard, Kolb, E. Anders, Lock, Richard, Carol, Hernan, Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Wu, Jianrong, Smith, Malcolm A., Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874079/
https://ncbi.nlm.nih.gov/pubmed/20108338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22430
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