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Initial Testing of the Aurora Kinase A Inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
BACKGROUND: MLN8237 is a small molecule inhibitor of Aurora Kinase A (AURKA) that is currently in early phase clinical testing. AURKA plays a pivotal role in centrosome maturation and spindle formation during mitosis. PROCEDURES: MLN8237 was tested against the Pediatric Preclinical Testing Program (...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874079/ https://ncbi.nlm.nih.gov/pubmed/20108338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22430 |
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