Initial Testing of the Investigational NEDD8 Activating Enzyme Inhibitor MLN4924 by the Pediatric Preclinical Testing Program

BACKGROUND: MLN4924 is an investigational first-in-class small molecule inhibitor of NEDD8-activating enzyme (NAE). NAE is an essential component of the NEDD8 conjugation pathway, controlling the activity of a subset of ubiquitin-proteasome system (UPS) E3 ligases, multiprotein complexes that transf...

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Main Authors: Smith, Malcolm A., Maris, John M., Gorlick, Richard, Kolb, E. Anders, Lock, Richard, Carol, Hernan, Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Morton, Christopher L., Wu, Jianrong, Smith, Peter G, Yu, Jie, Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823062/
https://ncbi.nlm.nih.gov/pubmed/22012946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23357
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