Initial Testing of Topotecan by the Pediatric Preclinical Testing Program

BACKGROUND: Topotecan is a small molecule DNA topoisomerase I poison, that has been successful in clinical trials against pediatric solid tumors and leukemias. Topotecan was evaluated against the PPTP tumor panels as part of a validation process for these preclinical models. PROCEDURES: In vivo thre...

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Detalhes bibliográficos
Main Authors: Carol, Hernan, Houghton, Peter J., Morton, Christopher L., Kolb, E. Anders, Gorlick, Richard, Reynolds, C. Patrick, Kang, Min H., Maris, John M., Keir, Stephen T., Watkins, Amy, Smith, Malcolm A., Lock, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923808/
https://ncbi.nlm.nih.gov/pubmed/20017204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22352
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