Initial Testing (Stage 1) of the Multi-targeted Kinase Inhibitor Sorafenib by the Pediatric Preclinical Testing Program

BACKGROUND: Sorafenib is an inhibitor of multiple kinases (e.g., VEGF receptors, PDGFR, FLT3, RET, BRAF, KIT) and is approved by FDA for treatment of two adult cancers. The activity of sorafenib was evaluated against the PPTP's in vitro and in vivo panels. PROCEDURES: Sorafenib was evaluated ag...

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Autores principales: Keir, Stephen T., Maris, John M., Lock, Richard, Kolb, E. Anders, Gorlick, Richard, Carol, Hernan, Morton, Christopher L., Reynolds, C. Patrick, Kang, Min H., Watkins, Amy, Houghton, Peter J., Smith, Malcolm A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823056/
https://ncbi.nlm.nih.gov/pubmed/20672370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22712
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