Initial Testing (Stage 1) of Mapatumumab (HGS-ETR1) by the Pediatric Preclinical Testing Program

Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that exclusively targets and activates tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). It was tested in vitro at concentrations from 0.01 to 100 μg/ml and in vivo at a dose of 10 mg/kg administe...

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Главные авторы: Smith, Malcolm A., Morton, Christopher L., Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Carol, Hernan, Lock, Richard, Kang, Min H., Reynolds, C. Patrick, Maris, John M., Watkins, Amy E., Houghton, Peter J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794954/
https://ncbi.nlm.nih.gov/pubmed/19856388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22188
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