Initial Testing (Stage 1) of Mapatumumab (HGS-ETR1) by the Pediatric Preclinical Testing Program

Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that exclusively targets and activates tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). It was tested in vitro at concentrations from 0.01 to 100 μg/ml and in vivo at a dose of 10 mg/kg administe...

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Main Authors: Smith, Malcolm A., Morton, Christopher L., Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Carol, Hernan, Lock, Richard, Kang, Min H., Reynolds, C. Patrick, Maris, John M., Watkins, Amy E., Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794954/
https://ncbi.nlm.nih.gov/pubmed/19856388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22188
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