Initial Testing (Stage 1) of AT13387, an HSP90 Inhibitor, by the Pediatric Preclinical Testing Program

AT13387, a non-geldanamycin inhibitor of heat-shock protein 90 (HSP90), was tested against the PPTP in vitro panel (1.0 nM to 10 μM) and against the PPTP in vivo panels (40 mg/kg or 60 mg/kg) administered orally twice weekly. In vitro AT13387 showed a median EC(50) value of 41 nM and exhibited activ...

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書誌詳細
主要な著者: Kang, Min H., Reynolds, C. Patrick, Houghton, Peter J., Alexander, Denise, Morton, Christopher L., Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Carol, Hernan, Lock, Richard, Maris, John M., Wozniak, Amy, Smith, Malcolm A.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154460/
https://ncbi.nlm.nih.gov/pubmed/21538821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23154
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