Initial Testing (Stage 1) of Ganetespib, an Hsp90 Inhibitor, by the Pediatric Preclinical Testing Program

Ganetespib, an Hsp90 inhibitor, was tested against the PPTP in vitro cell line panel and selected xenografts in vivo, including JAK2- and BRAF-mutated models. Ganetespib demonstrated potent in vitro cytotoxic activity (median rIC(50) 8.8 nM, range 4.4–27.1 nM). In vivo, ganetespib induced significan...

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Detaylı Bibliyografya
Yayımlandı:Pediatr Blood Cancer
Asıl Yazarlar: Lock, Richard B., Carol, Hernan, Maris, John M., Kang, Min H., Reynolds, C. Patrick, Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Billups, Catherine A., Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225043/
https://ncbi.nlm.nih.gov/pubmed/23303741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24451
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