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Initial Testing (Stage 1) of Ganetespib, an Hsp90 Inhibitor, by the Pediatric Preclinical Testing Program
Ganetespib, an Hsp90 inhibitor, was tested against the PPTP in vitro cell line panel and selected xenografts in vivo, including JAK2- and BRAF-mutated models. Ganetespib demonstrated potent in vitro cytotoxic activity (median rIC(50) 8.8 nM, range 4.4–27.1 nM). In vivo, ganetespib induced significan...
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| Publicado no: | Pediatr Blood Cancer |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4225043/ https://ncbi.nlm.nih.gov/pubmed/23303741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24451 |
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