Initial Testing (Stage 1) of Ganetespib, an Hsp90 Inhibitor, by the Pediatric Preclinical Testing Program

Ganetespib, an Hsp90 inhibitor, was tested against the PPTP in vitro cell line panel and selected xenografts in vivo, including JAK2- and BRAF-mutated models. Ganetespib demonstrated potent in vitro cytotoxic activity (median rIC(50) 8.8 nM, range 4.4–27.1 nM). In vivo, ganetespib induced significan...

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Publicat a:Pediatr Blood Cancer
Autors principals: Lock, Richard B., Carol, Hernan, Maris, John M., Kang, Min H., Reynolds, C. Patrick, Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Billups, Catherine A., Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225043/
https://ncbi.nlm.nih.gov/pubmed/23303741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24451
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