Initial Testing (Stage 1) of the Phosphatidylinositol 3’ Kinase Inhibitor, SAR245408 (XL147) by the Pediatric Preclinical Testing Program

BACKGROUND: Activation of the PI3 kinase pathway occurs frequently in many adult cancers and is implicated in tumor cell proliferation, survival, and resistance to chemotherapy and radiotherapy. However, less is known regarding the relevance of this pathway in pediatric cancers. Here we have evaluat...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Reynolds, C. Patrick, Kang, Min H., Carol, Hernan, Lock, Richard, Gorlick, Richard, Kolb, E. Anders, Kurmasheva, Raushan T., Keir, Stephen T., Maris, John M., Billups, Catherine A., Houghton, Peter J., Smith, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684943/
https://ncbi.nlm.nih.gov/pubmed/23002019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24301
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