Initial Testing (Stage 1) of the Phosphatidylinositol 3’ Kinase Inhibitor, SAR245408 (XL147) by the Pediatric Preclinical Testing Program

BACKGROUND: Activation of the PI3 kinase pathway occurs frequently in many adult cancers and is implicated in tumor cell proliferation, survival, and resistance to chemotherapy and radiotherapy. However, less is known regarding the relevance of this pathway in pediatric cancers. Here we have evaluat...

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Publicado en:Pediatr Blood Cancer
Autores principales: Reynolds, C. Patrick, Kang, Min H., Carol, Hernan, Lock, Richard, Gorlick, Richard, Kolb, E. Anders, Kurmasheva, Raushan T., Keir, Stephen T., Maris, John M., Billups, Catherine A., Houghton, Peter J., Smith, Malcolm A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684943/
https://ncbi.nlm.nih.gov/pubmed/23002019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24301
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