Initial Testing of Aplidin by the Pediatric Preclinical Testing Program

Aplidin was tested in vitro at concentrations ranging from from 0.1 nM to 1.0 μM and in vivo at a dose of 0.6 mg/kg administered intraperitoneally on an every 4 days × 3 schedule that was repeated at day 21. In vitro, Aplidin was most active against acute lymphoblastic leukemia (ALL) cell lines. In...

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Bibliographic Details
Main Authors: Morton, Christopher L., Houghton, Peter J., Gorlick, Richard, Kolb, E. Anders, Lock, Richard, Carol, Hernan, Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Maris, John M., Billups, Catherine, Smith, Malcolm A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777698/
https://ncbi.nlm.nih.gov/pubmed/19418543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.21976
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