TMOD-27. EFFICACY OF SOLUBLE PANOBINOSTAT (MTX110) IN PRECLINICAL MODELS OF ADULT GLIOBLASTOMA

INTRODUCTION: Panobinostat is a histone deacetylase (HDAC) inhibitor with antineoplastic and anti-angiogenic effects in glioma. HDAC inhibitors have demonstrated therapeutic efficacy preclinically via multiple mechanisms, including the induction of cell-cycle arrest, differentiation, senescence, apo...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Ashley, David, Keir, Stephen T, Roskoski, Martin A, Davies, Rhian, Williams, Ben, Damment, Stephen J P, Conlon, Kelly
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Tumor Models
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651368/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.977
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