Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells

Under normal physiologic conditions, the glutathione S-transferase P1 (GSTP1) protein exists intracellularly as a dimer in reversible equilibrium with its monomeric subunits. In the latter form, GSTP1 binds to the mitogen-activated protein kinase, JNK, and inhibits JNK downstream signaling. In tumor...

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Foilsithe in:J Biol Chem
Main Authors: Okamura, Tatsunori, Antoun, Gamil, Keir, Stephen T., Friedman, Henry, Bigner, Darell D., Ali-Osman, Francis
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692215/
https://ncbi.nlm.nih.gov/pubmed/26429914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656140
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