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The role of glutathione S-transferase P1-1 (GSTP1-1) in the cellular detoxification of cisplatin

Cells expressing elevated levels of allelic variants of human GSTP1 and/or efflux transporters, MRP 1 or 2, were used to evaluate the role of GSTP1-1 in cisplatin resistance. These studies revealed that GSTP1-1 confers low-level resistance (1.4–1.7-fold) to cisplatin-induced cytotoxicity in MCF7 cel...

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Bibliografski detalji
Glavni autori: Peklak-Scott, Christina, Smitherman, Pamela K., Townsend, Alan J., Morrow, Charles S.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587032/
https://ncbi.nlm.nih.gov/pubmed/18852128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0250
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